Miguel Díaz-Canel spoke to crowds in Havana the US is attempting to destroy Cuba’s political system.
He said America aims for complete control over the island.
Díaz-Canel described US policies a case of political genocide during July 26 events.
He stressed this is a threat to Cuba’s right to govern.
Raúl Castro was absent from the biggest rally.
Tensions remain high as a result of sanctions and American political pressure.